PDE5is inhibit cGMP-dependent PDE5 in the penile corporal
smooth muscle, and their efficacy is based on their ability to block the cGMP break-down produced by the nitric oxide (NO) -dependent activation of guanylyl cyclase
Wirkungen
- PDE5is inhibit cGMP-dependent PDE5 in the penile corporal
smooth muscle, and their efficacy is based on their ability to block the cGMP break-down produced by the nitric oxide (NO) -dependent activation of guanylyl cyclase - Tadalafil modulates the Cyp19a1 (ARO) activity and the expression and function of the androgen receptor (AR) in lines of bone, breast, prostate, adipose and muscle cells.
- Administration of tadalafil in men with ED was associated with an increase of the serum testosterone/estradiol (T/E2) ratio, mainly due to a significant reduction of E2 levels.
Greco, E.A.; Pili, M.; Bruzziches, R.; Corona, G.; Spera, G.; Aversa, A. Testosterone:estradiol ratio changes associated with long-term tadalafil administration: A pilot study. J. Sex. Med. 2006, 3, 716–722. [CrossRef] https://doi.org/10.1007/s11377-016-0075-7
- Ability to improve insulin secretion and reduce visceral fat mass.
Aversa, A.; Greco, E.; Bruzziches, R.; Pili, M.; Rosano, G.; Spera, G. Relationship between chronic tadalafil administration and improvement of endothelial function in men with erectile dysfunction: A pilot study. Int. J. Impot. Res. 2007, 19, 200–207.
[CrossRef]
Indikationen
notes
- Small PDE5 amounts are present in different extra-genital tissues from humans, such as skeletal muscle and heart, lung, and adrenal gland tissue.
Morelli, A.; Filippi, S.; Mancina, R.; Luconi, M.; Vignozzi, L.; Marini, M.; Orlando, C.; Vannelli, G.V.; Aversa, A.; Natali, A.; et al. Androgens regulate phosphodiesterase. Type 5 expression and functional activity in corpora cavernosa. Endocriniogy 2004, 145, 2253–2263. [CrossRef] https://doi.org/10.1007/s11377-016-0075-7